| abstract |
The invention cell division, cell proliferation and thymosin between the Ras signaling pathway that plays an important role in the angiogenic process with the target β 10 (thymosin β 10) on the vessel of the protein neovascularization, cell growth or cell a new use as metastasis inhibitors will be. Specifically, the thymosin β 10 protein binds to and sequesters Ras-GTP or interferes with binding of Ras-GTP to Raf, thereby reducing the amount of Ras-GTP / Raf complex to inhibit the expression of endothelial progenitors. Can inhibit angiogenesis, cell metastasis and / or cell proliferation that occurs in humans. Therefore, the thymosin β 10 protein of the present invention may be used in various solid cancers such as angiogenesis, cell proliferation and / or cell metastasis associated with activity of the Ras signaling pathway, for example, ovarian cancer, cervical cancer, gastric cancer and lung cancer, It can be effectively used for the treatment of rheumatoid arthritis, psoriasis and diabetic retinopathy. |