| abstract |
An object of the present invention is to provide an amide derivative or salt thereof having excellent inhibitory activity of BCR-ABL tyrosine kinase.n n n The present invention comprises an amide derivative represented by the following formula (1) or a salt thereof and a pharmaceutical composition comprising these as an active ingredient:n n n n Formula 1n n n n n n n n n In the formula, R 1 represents -CH 2 -R 11 (R 11 represents a nitrogen-containing saturated heterocyclic group) and the like, R 2 represents alkyl, halogen, haloalkyl and the like, R 3 represents hydrogen and the like, Het1 is And the like, and Het2 represents pyrimidinyl and the like.n n n The compounds of the present invention are useful as BCR-ABL tyrosine kinase inhibitors. |