| abstract |
An object of the present invention is to provide a prophylactic or therapeutic drug for diabetic macular disease that exhibits efficacy by a mechanism different from existing drugs and can be used for a long time.n n n The present invention is a general formulan n n n n n n n (Wherein X represents a halogen or a hydrogen atom, R 1 and R 2 simultaneously or respectively represent a hydrogen atom, a C 1-6 alkyl group which may be substituted, or R 1 and R 2 are both nitrogen 5 to 6 membered heterocycle with atoms or with other nitrogen or oxygen atoms.)n n n It is a prophylactic or therapeutic agent of diabetic macular disease using the compound shown as an active ingredient. Especially, as a compound, (2S, 4S) -6-fluoro-2 'and 5'- dioxo spiro [Chroman-4, 4'- imidazolidine] -2-carboxamide are preferable.n n n The present invention also provides a model animal of diabetic macular disease in which diabetic animals are treated with intraocular ischemia and reperfusion, and the edema is expressed in the retinal cell layer or the macula. |