| abstract |
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof:n n n Formula In n n n n n n n Wheren n n R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , X 2 , X 3 , X 4 , n and k are as defined in the description and claims of the invention.n n n Compounds include increased lipid and cholesterol levels, in particular low HDL-cholesterol, high LDL-cholesterol, atherosclerosis, diabetes mellitus, especially non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, colitis and Treating and treating diseases modulated by LXRα and / or LXRβ agonists, including inflammatory diseases such as pancreatitis, hepatic stagnation / fibrosis, and diseases with inflammatory elements such as Alzheimer's disease and impaired / improveable cognitive function It is useful for prevention. |