| abstract |
The present invention provides compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors. In particular, there is provided a compound for use in compositions and methods for modulating the Farnesoid X receptor, ie a compound of formula (I) or a pharmaceutically acceptable derivative thereof:n n n n n n n n Wheren n n R 1 is —C (J) OR 14 , —C (J) SR 14 and —C (J) N (R 15 ) R 16 ;n n n J is O, S or NR 17 ;n n n R 2 is hydrogen, halo or substituted or unsubstituted alkyl;n n n R 3 is —C (O) R 9 ;n n n R 4 , R 5 , R 6 and R 7 are as described in the claims. |