| abstract |
The present invention provides β-adrenergic effect blockers nitrooxyderivatives of general formula (I):n n n A- (Y-ONO 2 ) s n n n Where s is an integer equal to 1 or 2;n n n A is selected from the following β-adrenergic potency blocker residues of formula (II):n n n R 1 is selected from the group consisting of: formula (IIa), formula (IIb), formula (IIc),n n n Or other residues as defined in claim 1; R2 is selected from the group consisting of; -CH (CH3) 2, -C (CH3) 3 or formula (IIIa), formula (IIIb), Z is H or a group capable of bonding to Y as defined in claim 1: Z1 is bonded to H or Y -C (O)-which can be; Other substituents are defined in claim 1; And their enantiomers and diastereomers and pharmacologically acceptable salts, pharmaceutical compositions comprising them and their use for the treatment of hypertension, cardiovascular disease, glaucoma, migraine and vascular diseases. |