http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20060119612-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be7e051d2da759ca1f54f10dc5b175ba |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 |
| filingDate | 2005-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d7ef0e1b469527226fe18eff5f0446e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50c0a6107646bbde9eb7aa72f6980028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_462d911320b356cbef7153803a88e264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5592653a4893e4efe22ad49840259a5f |
| publicationDate | 2006-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20060119612-A |
| titleOfInvention | Preparation of Micronized Arbutin Formulation Using Supercritical Fluid Process |
| abstract | The present invention relates to a miniaturized arbutin preparation using a supercritical fluid process, comprising: contacting by spraying a mixed solution of arbutin dissolved in an organic solvent into a supercritical fluid to generate arbutin particles and introducing a supercritical fluid into the particles. The present invention relates to a method of preparing ultrafine arbutin particles using a supercritical fluid process, which includes removing the organic solvent used in the mixed solution. In the method of the present invention, the particle size of the drug is miniaturized by changing the crystallinity of the drug itself through a change in temperature and pressure, which are operating variables of a supercritical fluid process, or a flow rate of a solution of arbutin and an organic solvent and supercritical carbon dioxide. Enhancement of skin efficacy due to increase may be usefully used in the preparation of arbutin preparations foreseen. |
| priorityDate | 2005-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.