| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70f1b701d26bef2d534c162c3611ac25 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2005-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d37c7b92dbc75ddd05ae64e53c7b0ba2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_217f97bbb4915641f0b503d8855fe2d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aac02e1eb4033df3fa774cc9d403167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_025642cc73bfdf1a6025ec044b5e05f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1788932212f8b219dd64d858fbb98b5 |
| publicationDate |
2006-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20060114011-A |
| titleOfInvention |
Chaperonin 10 Regulation of Tacter-like Receptor Induced Cytokine and Chemokine Secretion |
| abstract |
The present application relates to methods of using chaperonin 10 (Cpn10) to modulate Toll-like receptor signaling and / or Toll-like receptor induced immunomodulatory secretion. Cpn10 negatively regulates the secretion of Toll-like receptor agonist-induced pro-inflammatory cytokines and chemokines such as IL-6 and RANTES, respectively. Cpn10 positively regulates the secretion of Toll-like receptor agonist-induced anti-inflammatory cytokines and chemokines such as IL-10. Such immunomodulatory activity of Cpn10 may be useful for modulating diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. The present invention also relates to methods of generating, designing and / or screening Cpn10 agonists and antagonists according to their ability to modulate Toll-like receptor signaling and / or Toll-like receptor induced immunomodulatory secretion. |
| priorityDate |
2004-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |