| abstract |
The present invention provides a novel process for decomposing mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; Decomposed mandelic acid cyclic amide salts (see, eg, Formula IIa); It relates to other specific metal and amine salts of the mandelic acid derivatives and to the use of such decomposed mandelic acid derivatives as intermediates suitable for large scale preparation of, for example, pharmaceutical compounds.n n n Formula IIan n n n n n n n Wherein R is selected from CHF 2 , H, C 1-6 alkyl, CH 2 F, CHCl 2 and CClF 2 ; n is 0, 1 or 2; R 1 is H or C 1-6 alkyl; X is H, halo or C 1-6 alkyl. |