| abstract |
The present invention is a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis, more specifically, N-substituted-N-sulfonylaminocyclopropane compound of the formula (1), Or prodrugs thereof or pharmaceutically acceptable salts thereof:n n n [Formula 1]n n n n n n n n In the formula, and R 1 is -WA 1 -W 1 -A 2, W is - (CH 2) m -X- ( CH 2) n - , wherein W 1 is - (CH 2) m1 -X 1 -(CH 2 ) n1- , m, m1, n and n1 are the same or different, each is 0 to 6, X and X 1 are the same or different, each is a single bond and the like, A 1 is optionally substituted a C 3 -14 or the like hydrocarbon ring group, a 2 is a substituted C 3 -14 hydrocarbon ring group or the like; R 2 is - (CH 2) a -CO-R 8, such as r, where r is from 0 to 6, R 8 are such as C 1 -6 alkoxy group and; R 3 and R 4 are identical or different, each represent a hydrogen atom, C 1 -6 alkyl group or the like; R 5 is —CO 2 R 21 or the like; R 30 and R 31 are the same or different and each is a hydrogen atom or the like]. |