| abstract |
Diseases associated with tissue in the posterior segment of the eye can be effectively treated by transdermally administering a therapeutic agent to these tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions near or in the sclera, and implanting solid structures containing the therapeutic agent near or in the sclera. Include. Such methods may be used to administer rapamycin or related compounds to treat choroidal neovascularization associated with age related macular degeneration. |