| abstract |
The present invention relates to the use of a compound of formula (I), N-oxides, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof for the manufacture of a medicament for the treatment of a subject infected with HIV (Human Immunodeficiency Virus). will be:n n n n n n n n In the above formula,n n n A is CH, CR 4 or N;n n n n is 0 to 4;n n n Q is hydrogen or -NR 1 R 2 ;n n n R 1 and R 2 is hydrogen, hydroxy, C 1 - 12 alkyl, C 1 - 12 alkyloxy, C 1 - 12 alkylcarbonyl, C 1 -12 alkyl oxy carbonyl, aryl, amino, mono- or di ( C 1-12 alkyl) amino, mono- or di (C 1-12 alkyl) aminocarbonyl orn n n (Wherein, C 1 - 12 alkyl group may be optionally substituted, respectively);n n n R 1 and R 2 together is pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di (C 1-12 alkyl) amino C 1 - 4 can form an alkylidene and;n n n R 3 is hydrogen, aryl, C 1 - 6 alkylcarbonyl, optionally substituted C 1 - 6 alkyl, C 1 - 6 alkyloxycarbonyl, and;n n n R 4 is hydroxy, halo, an optionally substituted C 1 - 6 alkyl, C 1 - 6 alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, methyl, methyloxy, and trihaloalkyl;n n n R 5 is hydrogen or C 1 - 4 alkyl;n n n L is an optionally substituted C 1 - 10 alkyl, C 3 - 10 alkenyl, C 3 - 10 alkynyl, C 3 - 7 cycloalkyl, or;n n n L is -X 1 -R 6 or -X 2 -Alk-R 7 n n n (From here,n n n R 6 and R 7 are optionally substituted phenyl;n n n X 1 and X 2 are —NR 3 —, —NH—NH—, —N═N—, —O—, —S—, —S (═O) — or —S (═O) 2 —;n n n Alk is C 1 - 4 is alkanediyl);n n n Aryl is optionally substituted phenyl;n n n Het is an optionally substituted aliphatic or aromatic heterocycle radical.n n n The present invention also relates to novel compounds which are subgroups of the compounds of formula (I), methods for their preparation and pharmaceutical compositions comprising them. |