| abstract |
The present invention relates to a (chromen-6-carbonyl) guanidine derivative, a preparation method thereof, and an agent for preventing and treating ischemic heart disease including the same. The (chromen-6-carbonyl) guanidine derivatives of the present invention enhance cardiac function recovery against ischemia / reperfusion injury and reduce myocardial infarction rate through a potent inhibitory action on sodium / hydrogen exchange pathway NHE-1. By protecting the cells, it can be used as an agent for the prevention and treatment of ischemic heart diseases such as myocardial infarction, heart failure, angina pectoris, and cardioprotection during reperfusion therapy such as coronary artery bypass surgery, coronary percutaneous plastic surgery, or drug therapy using thrombolytics. Can be used zero. |