| abstract |
Recombinant influenza virus proteins, including influenza capsomers, subviral particles, virus analogs (VLPs), VLP complexes, and / or portions thereof, are provided as vaccines for influenza viruses. The present invention is very immune, consisting of two vaccine technologies: (1) inherently safe recombinant vaccine technology, and (2) multiple copies of influenza virus structural proteins inserted into the plasma membrane and exhibiting neutralizing epitopes in their native form, It is based on a combination of protein polymers that are self bound. More specifically, the invention relates to functional isoform and heterologous recombinant influenza consisting of recombinant structural proteins of human influenza virus type A / Sydney / 5/94 (H3N2) and / or avian influenza virus type A / Hong Kong / 1073/99 (H9N2). Design of virus like particles (VLPs) and their production in baculovirus infected insect cells and their use as preventive vaccines for influenza infection and as experimental reagents for viral structure studies and clinical diagnostics.n n n n Influenza Virus Similar Particles, Recombinant Influenza Virus Proteins |