| abstract |
Scheme ofn n n n n n n n (Wherein Ra, Rb and Rd are substituents and Rc represents a group that can be removed by an acid), and Rc-X (2) is reacted with compound (1) to obtain compound (3), A method for producing 1,2,4-triazole compound (5), salts or hydrates thereof in which a nitriding agent is reacted to obtain compound (4), and then the group Rc is removed.n n n 2-cyanopyridine-4- which may inhibit the xanthine oxidase in high yield without isolating any of the reaction products from the compound (1) and having a substituent useful for the treatment of gout and hyperuricemia. 1,2,4-triazole compound (5) which has a diary in 3-position and has the aromatic group which may have a substituent in 5-position can be manufactured. |