| abstract |
Template-immobilized β-hairpin peptide mimetics of the general formula:n n n n n n n n Wherein Z is a template anchored chain of 12, 14 or 18 α-amino acid residues, depending on the position in the chain (counting from the N-terminal amino acid), Gly, NMeGly, Pro or Pip, or As the remainder of the formula, certain types described in the present specification and claims, and salts thereof, the peptidomimetic have CXCR4 antagonistic properties, prevent HIV infection in healthy individuals or stop viral progression in infected patients or Slowing, or wherein the cancer or immune disease is mediated by or results from CXCR4 receptor activity, or for the treatment of immunosuppression; Or it is used for the component-specific collection of peripheral blood stem cells.n n n Such β-hairpin peptide mimetics can be synthesized by methods based on mixed solid- and solution phase synthesis strategies. |