| abstract |
The present invention provides a compound of formula 1 having a 2- (2-amino-4-pyrimidinyl) -4-aminophenol structure that inhibits the activity of VEGFR2 kinase (KDR), a method of preparing the same And to a pharmaceutical composition comprising the use thereof and a pharmacologically effective amount thereof. The compounds according to the invention show efficacy in the treatment and inhibition of diseases due to undesired KDR activity, for example diseases related to angiogenesis such as cancer, psoriasis, rheumatoid arthritis, diabetic retinopathy and the like.n n n (One)n n n Wherein R 1, R 2, R 3 and R 4 are as defined in the specification. |