| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa48a431ce250933eb0fdd7a1caf3f30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c94b0d745a74cbae1dae991e857c356a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03b2ec5f0e6c20b2e347d67ffdd52bed |
| publicationDate |
2006-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20060033711-A |
| titleOfInvention |
Methods of treating multi-drug resistant tumors |
| abstract |
Methods for administering mitomycin C to multi-drug resistant cells and methods for reducing the toxicity of mitomycin C are described. In this method, mitomycin C is provided in the form of a prodrug conjugate wherein the drug is bound to a hydrophobic site, such as a lipid, via a cleavable dithiobenzyl bond. Dithiobenzyl bonds are susceptible to cleavage by mild thiolysis, allowing mitomycin C to be released in their native form. The bond is stable under non-reducing conditions. Prodrug conjugates may be incorporated into liposomes for administration in in vivo reducing conditions or in response to administration of exogenous reducing agents. |
| priorityDate |
2003-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |