| abstract |
The present invention provides a ([1,3] thiazolo [5,4- b ] pyridin-2-yl) -2-aziridinecarboxamide structure that inhibits the activity of VEGFR2 kinase (KDR). The present invention relates to a compound represented by the following Chemical Formula 1, a preparation method thereof, a use thereof, and a pharmaceutical composition comprising the same in a pharmacologically effective amount. The compounds according to the invention show efficacy in the treatment and inhibition of diseases due to undesired KDR activity, for example diseases related to angiogenesis such as cancer, psoriasis, rheumatoid arthritis, diabetic retinopathy and the like.n n n (One)n n n Wherein R 1 , R 2 , R 3 and X are as defined in the specification. |