| abstract |
The present invention relates to a bitransgenic dementia mouse expressing a hPS2 mutant gene and a TAK gene, and more specifically, a hPS2m promoter and a promoter of a pTet gene, a recombinant gene which connects a promoter of the pTet gene to a TAK gene. Microinjection of recombinant genes linked to the genes into the fertilized eggs of the mice, and the production of transgenic mice produced by transplanting the fertilized eggs into the oviduct of the surrogate mother mice, and produced by crossing the transgenic mice Double transgenic dementia mice.n n n Transgenic dementia mice according to the present invention are capable of controlling expression of the PS2 gene and exhibit behavioral abnormalities similar to those of human dementia patients, amyloid β-42 accumulation, Tau protein activation, and catenin activation. In addition, it can be very useful for the development of treatment for dementia disease or early diagnosis of dementia disease.n n n n Dementia * Alzheimer's Disease * Tetracycline-induced Dementia Mice * PS2 * Amyloid β-42 * Tau Protein * Catenin |