abstract |
The present invention describes GnRH receptor antagonists that have utility in treating various sex-hormone related conditions in both men and women. Compounds of the present invention have a structure of Formula I and include stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R 1a , R 1b , R 1c , R 2a , R 2b , R 3 , R 4 , R 5 , R 6 and X are as defined in the present invention. In addition, the present invention describes a composition containing a compound of the present invention and a pharmaceutically acceptable carrier, and methods associated with its use to antagonize gonadotropin-releasing hormone in a subject in need thereof.n n n <Formula I> |