| abstract |
The present invention provides a method of preventing or treating a disease comprising disrupting sex steroid mediated signaling in a patient, thereby enhancing the functionality of bone marrow or other immune cells prior to or concurrent with reactivation of the thymus without reactivation of the thymus, Provided are methods for enhancing the immune response and improving the efficiency of gene therapy. In some examples, the sex steroid signaling may include LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective Discontinued or eliminated by administration of a progesterone response modulator (SPRM), ERD, aromatase inhibitor, or various mixtures thereof. |