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filingDate 2004-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2006-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20060021016-A
titleOfInvention Epithelial growth factor-polyethylene glycol conjugate and method for preparing the same
abstract The present invention relates to an epidermal growth factor-polyethylene glycol conjugate and a method for preparing the same, and more particularly, to a specific portion of an epidermal growth factor (EGF) derived from humans, that is, an amine group of lysine. And / or epithelial growth factor-polyethyleneglycol conjugates in which covalently bonded polyethylene glycol (PEG, Polyethylene Glycol), which is a polymer, to an amino-terminal amine group and a method for preparing the same. Therefore, the epidermal growth factor-polyethylene glycol conjugate according to the present invention can lower the degree of degradation in vivo as compared to the natural epidermal growth factor, and is remarkably stable against physicochemical factors such as heat, acid, and alkali, even outside the body. The effect can be obtained.n n n n Polyethylene glycol, epidermal growth factor, EGF, pegylation reaction, pegylation
priorityDate 2004-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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