| abstract |
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof:n n n Formula In n n n n n n n Wheren n n R 1 is phenyl or a heterocycle comprising nitrogen and / or oxygen;n n n R 2 is a group selected from the group consisting of the groups of formulas a to e, which is imidazole or cyclized imidazole;n n n Formula an n n n n n n n Formula bn n n n n n n n Formula cn n n n n n n n Formula dn n n n n n n n Chemical formula en n n n n n n n [Wherein,n n n R 3 is hydrogen, phenyl, 2,3-dihydro-benzo [1,4] dioxin-6-yl, benzo [b] thiophen-3-yl, 3-methyl-benzo [b] thiophen-2- One, thiophen-2-yl, thiophen-3-yl or thiophen-2-yl-methyl;n n n R 4 is hydrogen or lower alkyl;n n n R 5 is hydrogen, lower alkyl, halogen, morpholinyl, -NR'R ", piperidinyl, optionally substituted with hydroxy, or pyrrole-1-yl;n n n R 6 is hydrogen, benzyl or — (CH 2 ) n O-lower alkyl,n n n R 7 is hydrogen, -C (O) O-lower alkyl, -C (O) -C 6 H 4 -halogen, -C (O) -C 6 H 4 -lower alkyl, -C (O) -lower alkyl , -C (O) -cycloalkyl, -C (O) -NR'R ", -C (O)-(CH 2 ) n O-lower alkyl, -S (O) 2 -lower alkyl,-(CH 2 ) n O-lower alkyl or -C (O) -pyridin-4-yl, wherein the ring may be substituted by lower alkyl, halogen-lower alkyl or pyrrole-1-yl-methyl) or-(CH 2 ) n -C (O) -NR'R ";n n n R ′ and R ″ are, independently from each other, hydrogen, lower alkyl, or — (CH 2 ) n -tetrahydropyran-4-yl;n n n X is -CH 2- , -NR '"-or -O-;n n n R ′ ″ is hydrogen, —C (O) —lower alkyl, —C (O) O-lower alkyl, —C (O) —C 6 H 4 CH 3 or benzyl;n n n n is 1 or 2.n n n Since the compound is an adenosine receptor ligand, it is suitable for the treatment of diseases related to these receptors. |