http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20060002033-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ff6cabc93798fffb214d326e8906395 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 |
| filingDate | 1998-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a885f396f1b8874bee478b46814e1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecd8162d994e3df1d1d106527db1aedf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e4ffa3850200119895e5d55ed4f5f01 |
| publicationDate | 2006-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20060002033-A |
| titleOfInvention | Scheduled neuronal precursor |
| abstract | A population of hepatocytes scheduled for self-proliferation was identified by developing a spinal cord at day 13.5 of the embryo that can differentiate into a variety of neuronal phenotypes. Precursors (NRP) destined for these neurons express very high polysialated or embryonic neuronal adhesion molecules (E-NCAMs), are morphologically distinct from neuroepithelial hepatocytes (NEP cells), and spinal cord Cell progenitors were derived from spinal cord at day 10.5 of embryos. NRP cells multiply through various pathways in the presence of fibroblast growth factor (FGF) and neurotrophin-3 (NT-3) and express a specialized subset of neuronal epitopes. When cultured with RA present and lacking FGFs, NRP cells differentiate into GABA, glutamate and cholinergic immunoreactive neurons. NRP cells can be generated from multipotent NEP cells cultured from neural tubes at day 10.5 of the embryo. Clonal analysis showed that E-NCAM immunoreactive NRP cells originate from NEP progenitor cells producing other predetermined CNS precursors. E-NCAM immunoreactive cells derived from the NEP are self-proliferating in defined media and differentiate into phenotypes of various neurons in mass and clonal media. As such, there is a direct lineage relationship between more predetermined neuronal progenitor cells and multipotent NEP cells that are present in vivo at day 13.5 of the spinal cord embryo. The invention also discloses a method of treating a neurological disease. |
| priorityDate | 1997-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1188.