http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050119678-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
| filingDate | 2004-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c5502b4447c931c25c2be1f6fc7f3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f0ab97ec99a9f667f0b049b348315fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f725067266fc6b51d7a74952f4e495c |
| publicationDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050119678-A |
| titleOfInvention | A process for the preparation of 5-(haloacetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones |
| abstract | The present invention relates to a process for the preparation of 5- (α-haloacetyl) -8-substituted oxy- ( 1H ) -quinolin-2-ones. This method comprises the steps of (i) (a) reacting 8-hydroxy- ( 1H ) -quinolin-2-one with an acylating agent and Lewis acid to yield 5-acetyl-8-hydroxy- ( 1H ) -quinolin-2-one. To form; (b) reacting 8-hydroxy- ( 1H ) -quinolin-2-one with an acylating agent to form 8-acetoxy- ( 1H ) -quinolin-2-one and in situ 8-acetoxy- ( Treating 1H ) -quinolin-2-one with Lewis acid to form 5-acetyl-8-hydroxy- ( 1H ) -quinolin-2-one; Or (c) reacting 8-acetoxy- ( 1H ) -quinolin-2-one with Lewis acid to form 5-acetyl-8-hydroxy- ( 1H ) -quinolin-2-one; (ii) the 5-acetyl-8-hydroxy- ( 1H ) -quinolin-2-one prepared in step (i) is substituted with a compound and base of the formula RL wherein R is a protecting group and L is a leaving group; and Reacting in the presence of a solvent to form 5-acetyl-8-substituted oxy- ( 1H ) -quinolin-2-ones; (iii) 5-acetyl-8-substituted oxy- ( 1H ) -quinolin-2-one is reacted in the presence of a halogenating agent with a solvent to give 5- (α-haloacetyl) -8-substituted oxy- ( 1H ) Forming a quinoline-2-one. |
| priorityDate | 2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.