abstract |
The present invention relates to substituted-pyrimidone derivatives of formula (I) or salts thereof.n n n <Formula I>n n n n n n n n In the formula,n n n X represents two hydrogen atoms, one sulfur atom, one oxygen atom, a C 1-2 alkyl group or one hydrogen atom;n n n Y represents a bond, a carbonyl group, or an optionally substituted methylene group;n n n R 1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, wherein the ring is optionally substituted;n n n R2 represents a phenyl group or a naphthalene ring; Wherein the phenyl group and naphthalene ring are optionally substituted;n n n R 3 represents a hydrogen atom or a C 1-6 alkyl group;n n n R4 represents a C 1-2 perhalogenated alkyl group or a C 1-3 halogenated alkyl group;n n n R 5 represents hydrogen, a C 1-6 alkyl group or a halogen atom;n n n n represents 0 to 3;n n n p + q represents 0-3.n n n The present invention also relates to a medicament comprising the derivative or a salt thereof as an active ingredient for use in the prophylactic and / or therapeutic treatment of neurodegenerative diseases caused by abnormal activity of GSK3β such as Alzheimer's disease. |