| abstract |
The present invention includes, for example, a core comprising a fluorescent silane compound; And it provides a nanoparticle composition comprising a silica shell on the core. Also provided are methods of making nanoparticles comprising fluorescent nanoparticles, ligation-fluorescence nanoparticles, ligation-fluorescence nanoparticles carrying a therapeutic agent, and ligation-fluorescence nanoparticles associated or coupled with analyte. do. Also detection of ligated-fluorescent nanoparticles; Associating linked-fluorescent nanoparticles with cellular components of interest and monitoring or recording the movement of the cellular components; Improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination with a cell or organism; Methods are provided for preparing or using fluorescent nanoparticles in diagnostics, for example for the detection of various measurement objects, and for similar uses. |