http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050108682-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e559743173473475142b7bd8a978298 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 2004-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11e0a3413653805f3d077260da4c965d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9641b0777ae25f3ac94416ace98ba823 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db3b3eae7c899c888f0bb439c8c98eee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb98f5baeed4ee632352ec5f4e0e4209 |
| publicationDate | 2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050108682-A |
| titleOfInvention | An improved synthetic method of lacidipine |
| abstract | The present invention relates to an improved method for synthesizing lacidipine, and more particularly, to a method for synthesizing lacidipine, which has a simple process, easy reaction conditions, greatly improved yield, and mass production. In the present invention, phthalaldehyde and triphenylphosphoranylidene acetic acid 1,1-dimethylethyl ester are reacted to (E) -3- (2-formylphenyl) -2-propenic acid 1,1-dimethylethyl ester Preparing a first step; A second step of preparing lassidipine by reacting (E) -3- (2-formylphenyl) -2-propenic acid 1,1-dimethylethyl ester obtained in the above step with ethyl 3-aminocrotonate In the method of synthesizing lacidipine comprising the above step, the reaction is carried out at room temperature using tetrahydrofuran as a reaction solvent and recrystallized with hexane to obtain a yield of 100 ~ 110% (E) -3- (2 -Formylphenyl) -2-propenic acid 1,1-dimethylethyl ester crude product is obtained, and then the second step of the reaction is carried out as it is. |
| priorityDate | 2004-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.