| abstract |
The present invention relates to dihydrospiro- [cycloalkyl] -pyrimidone derivatives of formula (I)n n n <Formula I>n n n n n n n n Wheren n n X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C 1-2 alkyl group and a hydrogen atom;n n n Y represents a bond, a carbonyl group, or an optionally substituted methylene group;n n n R 1 represents a 2,3 or 4-pyridine ring or a 2,4 or 5-pyrimidine ring, wherein the ring is optionally substituted;n n n R 2 represents a benzene ring or a naphthalene ring with the ring optionally substituted;n n n R 3 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom;n n n m represents 1 to 4;n n n n represents 0 to 3;n n n p represents 0 to 2;n n n q represents 0-2 and p + q is less than 4.n n n The invention also relates to a medicament comprising the derivative or a salt thereof as an active ingredient, useful for the prophylactic and / or therapeutic treatment of neurodegenerative diseases caused by abnormal GSK3β activity such as Alzheimer's disease. |