| abstract |
In the present invention, the method for producing a fluorine-containing cyclic benzamidine derivative (A) or a salt thereof is characterized by comprising reacting a specific compound with ammonia or imide.n n n The method for producing a morpholine-substituted phenacyl derivative (B) or salt thereof of the present invention includes reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization reaction of the product. It features.n n n Moreover, the manufacturing method of the cyclic benzamidine derivative (C) or its salt of this invention is coupling compound (A) or its salt, and compound (B) or its salt in presence of ether or hydrocarbons, It is characterized by the above-mentioned. I am doing it.n n n The recrystallization method of the cyclic benzamidine derivative (C) or salt thereof according to the present invention comprises dissolving the compound (C) or a salt thereof in a mixed solvent of alcohols and water or a mixed solvent of ethers and water, Further, water is added to precipitate crystals of the compound (C) or salts thereof. |