abstract |
Isolated human monoclonal antibodies that specifically bind to IL-15 (eg, human IL-15), and related antibody-based compositions and molecules are disclosed. Human antibodies can be produced in transfectoma or non-human transgenic animals, such as transgenic mice, capable of producing several isotypes of human monoclonal antibodies by V-D-J recombination and isotype switching. Pharmaceutical compositions comprising said human antibodies, non-human transgenic animals, and hybridomas producing said human antibodies, and methods of treatment and diagnostics using said human antibodies are also disclosed. |