| abstract |
The present invention relates to novel peptides which are biologically active as ligands of platelet integrin GPIIbIIIa and α v integrins, preferably α v β 6 and α v β 3 integrins having the formula (I):n n n [Formula I]n n n R 1 -Arg-X-Asp-Leu-Asp-Ser-Leu-Arg-R 2 n n n [Wherein, R 1 represents H, acetyl or acyln n n R 2 represents —OH, OR 3 NH 2 , NHR 3 , N (R 3 ) 2 n n n R 3 represents alkyl, aralkyl, aryl, Hetn n n X represents an amino acid of formula (II)n n n [Formula II]n n n n n n n n [Wherein A represents (CH 2 ) n n n n R 4 represents H, alkyl, aralkyl or aryln n n n represents 1, 2, 3, 4, 5 or 6]n n n The amino acid of formula (II) is bound to the α-amino group of adjacent Asp via the peptide bond of the adjacent Arg and α-carboxyl group through the peptide bond of the α-amino group. |