| abstract |
The present invention relates to a process for preparing the following diaryl amine compounds of formula (I) or salts thereof, comprising coupling a compound of formula (II) with an amine of formula (III) in the presence of an alkali metal salt or transition metal catalyst:n n n Formula In n n n n n n n Formula IIn n n n n n n n Formula IIIn n n n n n n n In the above formula,n n n Ar 1 and Ar 2 are independently Q; Q is an aryl or heteroaryl ring system, each optionally fused to a saturated or unsaturated 5-8 membered ring having 0-4 hetero atoms; Q is optionally substituted as defined in claim 1; X is a leaving group; Y is -C (O) -OZ; Z is selected from C 1 -C 6 aliphatic, benzyl, Fmoc, —SO 2 R ′ and Q, provided that Q is not substituted by X or alkyne; R 'is as defined in claim 1. |