| abstract |
The present invention relates to a novel product of formula (I).n n n Formula In n n n n n n n In Formula I above,n n n p is an integer from 0 to 2,n n n R and R1 are O or NH,n n n R2 and R3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, or R2 and R3 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic and all these radicals Optionally substituted,n n n A 1 is a single bond, alkyl, allyl or propynyl,n n n Y and Y 1 are H, OCF 3 , S (O) n CF 3 , S (O) n Alk, SO 2 CHF 2 , SO 2 CF 2 CF 3 , -O-CF 2 -CHF 2 , -O-CHF 2 , -O-CH 2 -CF 3 , SF 5 And SO 2 NR 5 R 6, wherein R 5 and R 6 are selected from hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl, or R 5 and R 6 are bonded to Together with nitrogen to form a heterocyclic radical),n n n A 2 is A 1 or CO and SO 2 ,n n n B 2 is a heterocyclic radical optionally substituted with one or more substituents selected from radicals as defined in Y 2 ,n n n R7 is a hydrogen atom or an alkyl, cycloalkyl, phenyl, acyl, S (O) 2 Alk, S (O) 2 aryl, S (O) 2 heteroaryl or S (O) 2 NR5R6 radical,n n n Y 2 is hydrogen, halogen, hydroxyl, cyano, alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -O-alkenyl, -O-alkynyl, -O-cycloalkyl, -S ( O) n - alkyl, -S (O) n - alkenyl, -S (O) n - alkynyl, S (O) n - cycloalkyl, COOR13, -OCOR13, NR5R6, CONR5R6 , S (O) n - NR5R6, -NR10-CO-R13, -NR10-SO 2 -R13, NH-SO 2 -NR5R6, -NR10-CO-NR5R6, -NR10-CS-NR5R6, -NR10-COOR13 (all these radicals are optionally substituted) )ego,n n n n is an integer of 0-2.n n n The product is in the form of isomers and salts thereof for medicaments. |