| abstract |
The present invention provides compounds of the formulas (I), (la) and (lb), and their pharmaceutically acceptable salts, solvates and prodrugs.n n n Formula In n n n n n n n Formula Ian n n n n n n n Formula Ibn n n n n n n n In the above formulas,n n n A is selected from C-X and N,n n n B is selected from C-Y and N,n n n R 1 is selected from H and (C 1 -C 6 ) alkyl,n n n R 2 is selected from H and (C 1 -C 6 ) alkyl,n n n X is selected from H, HO, C (O) NH 2 and NH 2 ,n n n Y is selected from H, HO, NH 2 , Br, Cl and F,n n n Z is selected from H, HO, F, CONH 2 and CN;n n n Provided that in the compounds of Formula (I), (Ia) or (Ib), A is CX, B is CY, R 1 is H or (C 1 -C 6 ) alkyl, and R 2 is H or (C 1 -C 6 ) alkyl, at least one of X, Y and Z must be OH;n n n In the compounds of formula (I), when A is CX, B is CY, Y is H, Z is H, R 1 is H and R 2 is H, X cannot be OH.n n n The compounds of the present invention are useful as dopamine agonists in the treatment of sexual dysfunction. |