http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050093801-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75f07838a8a23c74523afb6436a2ab3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_803a5a2f277256ad21983f2f8da2a724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a02a19757b09826fc9edcc59ae2d0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e0c5e38236c939190ada3c07caa922e |
| publicationDate | 2005-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050093801-A |
| titleOfInvention | A process for the preparation of racemic citalopram diol and/or s- or r-citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram |
| abstract | In the following, citalopram diol is 4- (4- (dimethylamino) -1- (4-fluorophenyl) -1-hydroxybutyl) -3- (hydroxymethyl as free base and / or acid addition salt. ) -Benzonitrile. FIELD OF THE INVENTION The present invention relates to a process for preparing racemic citalopram diol and / or R- or S-citalopram diol, which process comprises R- and S-citalopram diols having more than 50% of one enantiomer. The ratio of the non-racemic mixture of S- or R-citalopram diol and R-citalopram diol: S-citalopram diol is 1: 1 or closer to 1: 1 than the initial mixture. Separating into fractions containing R- and S-citalopram diols. The process comprises: (i) RS-citalopram diol is precipitated from a solution of the initial non-racemic mixture and R- or S-citalopram diol is dissolved in a solvent from the initial non-racemic mixture. The RS-citalopram diol is then left behind, and (ii) the formed residue / precipitate is separated from the final solution phase, followed by optional steps of repetition, recrystallization, purification, separation and conversion between free base and salt. It features. The present invention also relates to a process for the preparation of RS-citalopram, S-citalopram or R-citalopram (all as free base and / or acid addition salts), comprising the process described above followed by a ring closure. |
| priorityDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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