| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecd03acca85bf5758dc77fd44739c9bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 |
| filingDate |
2003-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ff4afb7760a193538c8157edfa63b69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b73e02d09ae574dac90a4eb2b7c456c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d50d26c87fbb547d22e47732a8625470
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1cbee5a946f06e5fae18a16cfb02cc0 |
| publicationDate |
2005-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20050092022-A |
| titleOfInvention |
Polymer conjugates of interferon-beta with enhanced biological potency |
| abstract |
Methods of synthesizing polymer conjugates of cytokines and their receptor-binding antagonists, in particular unglycosylated interferon-β, are provided which maintain very high biological efficacy. Preparation of the polymer conjugates according to the method of the present invention reduces the steric inhibition of receptor-ligand interactions generally caused as a result of the adhesion of polymers to receptor-binding regions of cytokines and their agonism and antagonist analogs. Or prevent it. The invention also provides conjugates and compositions prepared by such methods. The conjugates of the present invention maintain a higher level of biological efficacy than those produced by conventional polymer coupling methods that are not intended to avoid receptor-binding regions of cytokines. In in vitro assays, the biological efficacy of the conjugates of the nonglycosylated interferon-β of the present invention is substantially higher than that of the unconjugated interferon-β and is similar to that of the glycosylated interferon-β 1a. The conjugates of the invention also exhibit prolonged half-life in vivo when compared to the corresponding unconjugated cytokine. The invention also provides kits comprising such conjugates and / or compositions; Such conjugates and compositions are provided for use in a variety of diagnostic, prophylactic, therapeutic uses, including the treatment of multiple sclerosis. |
| priorityDate |
2002-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |