| abstract |
The present invention relates to an isolated nucleic acid corresponding to a BMP-2 regulatory site or fragment thereof comprising an estrogen response element, a vector comprising the nucleic acid, and a cell comprising the vector. In another aspect, the present invention provides a method of identifying estrogen agonists, estrogen antagonists and therapeutic agents, and in another embodiment the present invention is directed to treatment of conditions associated with estrogen deficiency or lack of response to external estrogens or agonists thereof. Provide a method. |