abstract |
The present invention relates to the preparation of a quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof, a method for preparing the same, a pharmaceutical composition containing the same, and a medicament for use as an anti-invasive agent in the inhibition and / or treatment of solid tumor diseases. It relates to their use.n n n Formula In n n n n n n n (Wherein Z is O, S, SO, SO 2 , N (R 2 ) or C (R 2 ) 2 groups, each R 2 group is hydrogen or (1-8C) alkyl, m is 0, 1 , 2 or 3, each R 1 group is selected from any one of halogeno, (1-8C) alkyl, (1-6C) alkoxy and other meanings defined in the specification, n is 0, 1, 2 or 3 Each R 3 group is selected from any one of halogeno, (1-8C) alkyl, (1-6C) alkoxy and other meanings defined in the specification) |