| abstract |
The present invention provides 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds represented by the formula:n n n [Formula 1]n n n n n n n n (In formula, R < 1> represents a hydrogen atom or a C1-6 alkyl group, n represents the integer of 0-6, R < 2> represents -OR < 3> group etc., R < 3> represents a hydrogen atom, a C1-C6 alkyl group, etc. R 1 and — (CH 2 ) n R 2 may be bonded to each other with a carbon atom adjacent to each other through a nitrogen atom to form a spiro ring represented by the following formula H:n n n [Formula H]n n n n n n n n [In formula, R < 41> is hydrogen, a C1-C6 alkyl group, etc.].n n n The compound has excellent bactericidal activity against Mycobacterium tuberculosis, Multidrug resistant tuberculosis bacteria and Atypical acidophilic bacteria. |