abstract |
It is intended to provide an antibody that selectively shows immune responsiveness to ADAMTS-13, epitope analysis of the antibody, or use in diagnosis of ADAMTS-13 autoantibody positive patients. Or methods of making and using partially deleted ADAMTS-13 modified molecules for use as pharmaceuticals. An antibody specific for ADAMTS-13, which is obtained from a warm-blooded animal immunosensitized with a polypeptide comprising part or all of the amino acid sequence of ADAMTS-13. A method for producing an antibody comprising the step of immunosensitizing a warm-blooded animal with a polypeptide comprising part or all of the amino acid sequence of ADAMTS-13. Provided are uses of the antibody, including detection and purification methods of ADAMTS-13, and partially deleted ADAMTS-13 modified molecules. |