| abstract |
The present invention relates to compounds of formula (I), in which D represents a Z-HET group or a -HET group, and is a five-membered heterocycle such as oxadiazolone of formula (II) or thiazolidinedione of formula (III), Z Is selected from the group consisting of-(CR 1 R 2 ) n -and-(CR 1 = CR 2 ) n- ; Or D represents Z = HET, and -Z- represents a -Z = HET group of formula IV or formula V together with a heterocycle, where -Z = represents -CR 1 =. The compounds are useful as inhibitors specific to group II human non-pancreatic secreted phospholipase A2 (PLA 2 -snph) and are particularly useful for treating inflammation. |