| abstract |
The present invention provides protected valacyclovir, ie, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1, 6-dihydro-6-oxo-9H-purin-9-yl) Methoxy] ethyl ester and methods for preparing the same. The present invention also provides a step of using a coupling agent to couple an amine protected valine selected from Nt-butoxycarbonyl valine and N-formyl valine with acyclovir to form a protected valacyclovir and protected Deprotecting valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The invention also relates to a composition containing pure valacyclovir in a pure form, a process for producing pure valacyclovir and a pure valacyclovir. |