| abstract |
In the present invention, N-acyl of DL-erythro-3-substituted serine represented by the following general formula (1) is subjected to subsidiary hydrolysis by L-aminoacylase or D-aminoacylase, and in the case of L-acylase The present invention relates to a method of obtaining an unreacted N-acyl-D-erythro-3-substituted serine and, in the case of D-aminoacylase, a hydrolyzed D-erythro-3-substituted serine. Is useful as an intermediate such as a drug, for example, a drug known to be useful as an anti-HIV drug (WO01 / 40227):n n n n n n n n Wheren n n R 1 represents an alkanoyl group having 1 to 10 carbon atoms, a benzoyl group, an alkanoyl group having 1 to 5 carbon atoms substituted by a halogen atom or a benzoyl group substituted by a halogen atom,n n n R 2 means a phenyl group or a cyclohexyl group. |