| abstract |
The present inventionn n n i) C 3-8 alkanols and / or C 1-8 alkanediols;n n n ii) fatty alcohols; Andn n n iii) a) alkane carboxylic acid alkyl esters and / or alkane dicarboxylic acid alkyl esters and / orn n n b) hydrophilic co-components and / orn n n c) a further solvent selected from triglycerides;n n n Optionally further conventional additivesn n n A single phase topical liquid substantially free of ethanol and water, comprising ascomycin, for example pimecrolimus, in a carrier excipient comprising a mixture of at least 40% w / w of a total component weight of the composition, A semisolid pharmaceutical composition is disclosed. |