http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050039749-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80c611f294551348a19ab7a913372c70 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 |
| filingDate | 2003-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3462a0836892e005e7291c49bab9a414 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a4965f7b4e75e7c92702b68ed74d9af |
| publicationDate | 2005-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050039749-A |
| titleOfInvention | Process for preparing rizatriptan |
| abstract | In particular,n n n Preparing a diazonium salt of aniline hydrochloride of formula II, followed by reduction and acidification to obtain hydrazine of formula III (a),n n n Reacting the hydrazine hydrochloride of formula III with α-keto-δ-valerolactone in situ to obtain a hydrazone of formula IV (b),n n n Fischer indole reaction of the hydrazone of formula IV to give pyranoindoleone of formula V, followed by optionally hydrolysis to yield the product of formula VI (c),n n n (D) obtaining a compound of formula VII by transesterifying the compound of formula V or esterifying its hydrolysis product of formula VI, d.n n n Converting the hydroxyl group of the compound of formula VII to dimethylamino to give an indole carboxylate of formula VIII (e),n n n Saponifying a 2-carboalkoxy group of a compound of formula VIII to obtain an indolecarboxylic acid of formula IX; andn n n Decarboxylation of the indolecarboxylic acid of formula (IX) to obtain rizatriptan and pharmaceutically acceptable salts thereof (g), the present invention relates to rizatriptan or a pharmaceutically acceptable method for preparing the same. The invention also relates to synthetic intermediates for obtaining rizatriptan. |
| priorityDate | 2002-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.