| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c8fb7e85a6f61273fe3472d4fc675e5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3038
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 |
| filingDate |
2002-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_857973b98c8f63342b838cee635012fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba4f5246efd6c153ba4d5a70278dda28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49c09185c37b0b23241b26b1ecb527c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ba49940b1222326be0684b2c4fb87b3 |
| publicationDate |
2005-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20050037478-A |
| titleOfInvention |
Human antibodies that have mn binding and cell adhesion-neutralizing activity |
| abstract |
The present invention consists of a monoclonal human MN antibody or MN antibody fragment targeting a GEEDLP repeat in the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four such identical GEEDLP repeats. Binding to the desired epitope can be demonstrated by competing ELISA, and the ELISA signal can be attenuated by incubation with a peptide containing this repeat (PGEEDLPGEEDLP). Such binding inhibition can also be demonstrated by Biacore assays, wherein binding of the antibody of interest to an immobilized MN or proteoglycan peptide can be inhibited by peptide repeats. In addition to binding to peptide repeats, human anti-MN antibodies can inhibit adhesion of CGL-1 cells to MN coated plastic plates. Human anti-MN antibodies have been used to diagnose and quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods. It is also provided by way of example that human anti-MN IgG1 mediates tumor cell lysis through antibody-dependent cell-mediated cytotoxicity. Therefore, such antibodies will be useful for the treatment of cancers in which MN is upregulated and may be useful in the diagnosis of cancers in which MN is upregulated. |
| priorityDate |
2001-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |