abstract |
Selective PDE4 inhibition is achieved by 4- (substituted-phenyl) -2-pyrrolidinone compounds. The present compounds show improved PDE4 inhibition compared to compounds such as rolipram and selectivity for inhibition of other groups of PDEs. Compounds of the invention are of formula (I) wherein R 1 , R 2 and R 3 are as defined herein.n n n <Formula I> |