abstract |
The present invention relates to novel sulfonamide derivatives of the formulas that inhibit the enzymatic activity of BACE (or beta-secretase). The sulfonamide derivatives can be effectively used to treat or prevent Alzheimer's disease or similar diseases caused by beta-amyloid production by inhibiting the enzyme activity of BACE.n n n n n n n n (Wherein A, R 1 , R 2 , R 3 and X are defined in the specification) |